Once synthesized, thyroid hormones are stored as part of thyroglobulin in which area of the thyroid gland?

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Multiple Choice

Once synthesized, thyroid hormones are stored as part of thyroglobulin in which area of the thyroid gland?

Explanation:
Hormone storage happens in the colloid inside the thyroid follicle. Thyroglobulin, produced by follicular cells, is released into this colloid-rich lumen, where iodine is added to tyrosine residues to form the iodinated thyroid hormones. The hormones stay bound to thyroglobulin in the colloid as a reservoir until a signal (like TSH) triggers endocytosis and proteolysis to release T3 and T4 into circulation. So the correct site is the colloid within the follicle.

Hormone storage happens in the colloid inside the thyroid follicle. Thyroglobulin, produced by follicular cells, is released into this colloid-rich lumen, where iodine is added to tyrosine residues to form the iodinated thyroid hormones. The hormones stay bound to thyroglobulin in the colloid as a reservoir until a signal (like TSH) triggers endocytosis and proteolysis to release T3 and T4 into circulation. So the correct site is the colloid within the follicle.

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